Integrative classification and analysis of multiple arrayCGH datasets with probe alignment

Integrative classification and analysis of multiple arrayCGH datasets with probe alignment ( supplementary document )

A hypergraph-based learning algorithm for classifying gene expression and arrayCGH data with prior knowledge

MOTIVATION Incorporating biological prior knowledge into predictive models is a challenging data integration problem in analyzing high-dimensional genomic data. We introduce a hypergraph-based semi-supervised learning algorithm called HyperPrior to classify gene expression and array-based comparative genomic hybridization (arrayCGH) data using biological knowledge as constraints on graph-based ...

Identification of BKCa channel openers by molecular field alignment and patent data-driven analysis

In this work, we present the first comprehensive molecular field analysis of patent structures on how the chemical structure of drugs impacts the biological binding. This task was formulated as searching for drug structures to reveal shared effects of substitutions across a common scaffold and the chemical features that may be responsible. We used the SureChEMBL patent database, which prov...

Image Classification via Sparse Representation and Subspace Alignment

Image representation is a crucial problem in image processing where there exist many low-level representations of image, i.e., SIFT, HOG and so on. But there is a missing link across low-level and high-level semantic representations. In fact, traditional machine learning approaches, e.g., non-negative matrix factorization, sparse representation and principle component analysis are employed to d...

Analysis of Array CGH Data for the Estimation of Genetic Tumor Progression

Analysis of ArrayCGH Data for the Estimation of Genetic Tumor Progression Laura Toloşi Master of Science Department of Computer Science Saarland University 2006 In cancer research, prediction of time to death or relapse is important for a meaningful tumor classification and selecting appropriate therapies. The accumulation of genetic alterations during tumor progression can be used for the asse...